About Omacor

Product overview

Your Patient's Omacor Prescription.

Omega-3-acid ethyl esters 90

Omacor is an evidence-based therapy for secondary prevention post-MI and endogenous hypertriglyceridaemia. For hypertriglyceridaemia it is to be used as a supplement to diet when dietary measures alone are insufficient to produce an adequate response: type IV in monotherapy; type IIB/III in combination with statins, when control of triglycerides is insufficient. 1

Omacor provides 460 mg EPA and 380 mg DHA in a single 1g capsule.

The value of Omacor has been established in a large randomised controlled trial (GISSI-P) with 11,324 patients over three and a half years2. In this study, Omacor reduced the relative risk of all-cause mortality by an additional 20% when added to other post-MI therapy (2.1% absolute risk reduction).

The following parameters were also improved by the addition of Omacor to the post-MI therapy used in GISSI-P. 2

  • Cardiovascular death relative risk reduction: 30% (2% absolute risk reduction)
  • Sudden death relative risk reduction: 45% (1.6% absolute risk reduction)

The survival benefit of Omacor is comparable to other post-MI therapies as demonstrated in other cardiovascular trials such as 4S and the Antiplatelet Trialists' Collaboration.3,4

Omacor is the only omega-3-containing product licensed for secondary prevention post-MI.

Dosage for secondary prevention post MI is one capsule daily: Rx Omacor 1g od.1

References:

  1. Omacor SmPC
  2. GISSI-P. Lancet 1999; 354: 447-455.
  3. 4S. Lancet 1994; 344: 1383-1389.
  4. Antiplatelet Trialists' Collaboration. Br Med J 1994; 308: 81-106.
  5. NICE Guideline. Post Myocardial Infarction. Secondary Prevention in primary and secondary care for patients following a myocardial infarction. Royal College of General Practitioners. May 2007.
  6. Joint British Societies. Heart 2005; 91(suppl v): v1-v52.
  7. Van der Wharf et al. Eur Heart J 2008; 29: 2909-2945.
  8. Kris-Etherton et al. Circulation 2002; 106: 2747-2757.
  9. Scottish Medicines Consortium. 90% omega-3 acid ethyl esters. Summary of Recommendations. Glasgow, 2002.
  10. Bayes-de-Luna A et al. Cardiovasc Drugs Ther 1994; 8(Suppl 2): 335-343.
  11. Leaf A et al. Circulation 2003; 107: 2646-2652.
  12. Den Ruijiter HM et al. Circulation 2008; 117: 536-544.
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